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Contraindicated (1)pentobarbital will lower the extent or effect of lumefantrine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadministration with potent CYP3A4 inducers may result in lowered serum concentrations and lack of antimalarial efficacypentobarbital will minimize the extent or effect of oxybutynin by affecti